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For instance, transformation of human cells by the src oncogene of the Rous sarcoma virus results in constitutive phosphorylation of the receptor -subunit, but addition of IGF-1 further increases the level of phosphorylation (Werner and Le Roith, 2000)

A 2026 review in the New England Journal of Medicine noted that questions about long-term dosing and durability of results remain open areas of research, not settled strategy