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The present review has collated the foremost categories of nutrients known to offer advantages in managing DED, encompassing EFAs, vitamins, trace elements, and phytochemicals, along with six additional groups of emerging nutrients supported by studies demonstrating their efficacy in alleviating symptoms of DED

In addition to its pro-differentiating actions, nicotinamide promotes neuronal survival, especially in oxidative stress environments, through various pathways, such as maintenance of protein kinase B (akt)-dependent phosphorylation of forkhead transcription factor (FOXO3a)

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Typically, 2-3 treatments are recommended for optimal results, but the exact number will be determined during a consultation with a qualified healthcare professional