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This was a small pilot study (6 participants) results are preliminary and require confirmation in larger trials

[6] Oral Dosing Guide Larazotide is an oral, luminally-acting peptide, so its dosing is a record of what appeared in the trials rather than a titration schedule and its most striking feature is an inverted dose-response, where the lowest maintenance dose is the one that worked

GLP-1, in addition to its known effects on stimulating beta-cell proliferation and inhibiting apoptosis, is involved in the modulation of trans-differentiation and de-differentiation processes [7]