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Ongoing and Future Research Ongoing research is looking at the long-term safety of tirzepatide, including any potential link to cancer

Theres a reason they are all gastrointestinal: GLP-1s impact gut hormones and slow down gastric emptying (or how quickly you digest food), which can trigger the side effects

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For instance, new research presented at ACC.25 in March 2025 indicated that tirzepatide improved kidney function and cardiovascular outcomes in patients with obesity and heart failure with preserved ejection ejection (HFpEF) compared with placebo at one year, showing a 38% lower rate of cardiovascular death or worsening heart failure