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doi: 10.3389/fmed.2025.1569732 Received 01 February 2025 Accepted 21 April 2025 Published 08 May 2025 Volume 12 - 2025 Edited by Divya Bhatia, NewYork-Presbyterian, United States Reviewed by Muhammad Imran Khan, Chonnam National University, Republic of Korea Edwin Patino, NewYork-Presbyterian, United States Updates Copyright 2025 Fu, Chen, Li and Peng

They work through completely different receptor systems and metabolic pathways

Hepatic synthesis of glutathione and nutritional substrates, co-factors, and other nutrients that influence metabolism 5-Methyl-tetrahydrofolate (5MTHF), system alanineserinecysteine (ASC), cystathionine--synthase (CBS), cystathionine gamma-lyase (CGL), electrophile response element (EpRE), glutathione-S-transferase (GST), glutamate cysteine ligase (GCL), glutathione reductase (GRx), glutathione peroxidase (GPx), glutathione synthetase (GSx), hydrogen peroxide (H 2 O 2 ), Nuclear factor erythroid factor-2-related factor 2 (Nrf2), S-adenosylmethionine (SAMe), S-adenosylhomocysteine (SAH), tetrahydrofolate (THF), thioredoxin reductase 1 (TRR1), water (H 2 O), cystine/glutamate antiporter system (x c )

In order to taper off Cymbalta safely, one may need to open the capsule and count the beads