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Cell 174, 15591570.e1522

Genistein administration induced Nrf2 enhancement by activation/phosphorylation of keap1, sirt1, MAPK-ERK1/2, PKC, and estrogen receptor in other cells or tissues, such as: hippocampal tissue, hypothalamic paraventricular nucleus, ovary, and Caco-2 cells [131, 135,136,137]

Impact of the components of metabolic syndrome on oxidative stress and enzymatic antioxidant activity in essential hypertension

A nutrient can be absorbed perfectly well, but still have poor bioavailability if: the liver uses a large portion immediately, the nutrient breaks down quickly in the bloodstream, it isnt stored properly, it cant enter cells efficiently, it isnt chemically active by the time it arrives, its used rapidly during stress, inflammation, or detoxification