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From experimental data of kinetic measurements of BRET, following vehicle and baseline corrections, quantification of induced responses from individual peptide concentrations was determined by calculating the net area under curve from the 10 min response (AUC 0-10min) ) in GraphPad Prism version 9.0.1 (GraphPad Software Inc., San Diego, CA)

10.1016/S0896-6273(00)80417-1 Neuron 148 ShiK.WoodK.ShiF

Dysbiosis disrupts intestinal integrity, leading to immune activation, oxidative stress, and inflammation, which contribute to insulin resistance, type 2 diabetes, and hypertension