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Selpercatinib (160 mg twice daily) showed remarkable and durable efficacy in MTC with or without prior vandetanib or cabozantinib treatment in phase 1/2 trials (LIBRETTO-001 trial) (Table 3) [34]

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It should be noted that differences in mRNA expression patterns between Mmp9 and Mmp2 upon LLC challenge observed in IGF1R-deficient mice could be related to their distinct functional implication in this context, since MMP9 but not MMP2 was reported to promote LLC tumorigenesis [26]

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