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Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease primarily characterized by loss of motor neurons in brain and spinal cord

It is important to emphasize that chronic, usually low-level peripheral inflammation, as well as neuroinflammation, are key links in the pathogenesis of diseases such as AD and PD

Their use has significantly increased in recent years as newer agents have been effective for improving glucose control and promoting weight loss, in addition to significant cardiovascular and renal benefits