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While the mechanisms responsible for these potent effects remain incompletely understood, contributors include altered postprandial nutrient delivery to the intestine, increased secretion of glucagon-like peptide 1 (GLP-1) by intestinal L cells, increased insulin secretion, intestinal mucosal adaptations, alterations in the gut-brain axis, and changes in bile acid content and composition (3, 4)

Overall GLP-1 prescribing rates (GLP-1 RA prescriptions per total prescriptions) in September 2025 remained stable relative to June 2025 (+4.6%)

Lifestyle changes remain the foundation of weight loss, and FDA-approved GLP-1 medications can also support weight loss (if your healthcare provider recommends that approach for you)

Semaglutide is also marketed under two other names, Wegovy (when sold for weight loss) and Rybelsus (in the form of a pill rather than an injection)