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En pacientes con retinopata diabtica, particularmente formas avanzadas, debe considerarse el riesgo de empeoramiento, ya que SUSTAIN-6 mostr un aumento en complicaciones de retinopata diabtica
In mice and non-human primates, dual GLP-1R/GCGR (glucagon receptor) agonists have been shown to induce excellent glycemic control and significantly greater weight loss than liraglutide monotherapy, increasing energy expenditure and reducing total energy intake by 6070% [158]