cruzi faces a variety of oxidative stressors of internal and external origin during its replication and differentiation in the insect (Figure 1)
As a dual amylin and calcitonin receptor agonist, cagrilintides mechanism of action centers on binding to the calcitonin receptor (CTR) and the amylin receptor subtypes AMYR, AMYR, and AMYR each formed by the CTR partnered with receptor-activity modifying proteins RAMP1, RAMP2, or RAMP3, respectively
Some of the dual GLP-1R/GCGR agonists, such as Survodutide (Boehringer Ingelheim, Ingelheim am Rhein, Germany) and Efinopegdutide (Merck & Co., Kenilworth, NJ, USA), have already obtained the FDA fast-track designation for treatment of MASH (Survodutide: LiverageTM programme, NCT06632444
PMID 9250994