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MSCs and exosomes were isolated from the umbilical cord tissue of Whartons jelly

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Before the promising therapeutic impact of miRNA can be realized, there are several challenges to be addressed, which include but not limited to targeted delivery of oligonucleotides to specific organs, tissues and cell types, poor bioavailability, limited tissue permeability (Stylianopoulos and Jain, 2013), potential drug resistance, and instability (Raemdonck et al., 2008)

In the STEP 1 trial (Wilding et al., NEJM 2021), which included adults with obesity or overweight with weight-related comorbidities, participants receiving semaglutide 2.4 mg achieved a mean weight loss of 14.9% compared to 2.4% with placebo over 68 weeks