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The periodic solution in Panel B of Figure 3, GSH(t), is quite stable, fluctuating only between 5,500 and 8,000 M (even though the steady state values vary between 4,151 and 8,516 M)

It's important to consider alternative causes of cold extremities, including Raynaud's phenomenon, peripheral arterial disease, medication effects (such as beta-blockers), anaemia, hypothyroidism, or vitamin B12 deficiency (particularly in patients also taking metformin)