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Studies show that patients with AD exhibit reduced vitamin E levels in plasma, serum and cerebrospinal fluid, and those receiving vitamin E supplementation experience slower cognitive decline and decreased oxidative stress compared with placebo-treated individuals (101,108)

and 4 a.m ( Melatonin (N-acetyl-5-methoxytryptamine) is synthesized from serotonin (5-hydroxytryptamine) through a two-step reaction ( Figure 2 )

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