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There are more environmental factors playing a role now
Targeted delivery of thermoresponsive polymeric nanoparticle-encapsulated lycopene: in vitro anticancer activity and chemopreventive effect on murine skin inflammation and tumorigenesis
However, genetic and molecular studies of these nevi have not identified risk in terms of prognosis or progression to malignancy, thus leading us to believe that histologic changes are the result of the location of these nevi at special sites (e.g., areas of friction or exposure to other agents).68 The main special sites are the breasts, skinfolds, scalp, genitals, and acral areas.68 The histologic changes typical of special site nevi are varied, although they often give cause for concern and include confluence of nests, a certain degree of pagetoid spread, areas of dermal fibrosis, inflammatory infiltrates, loss of melanocytic cohesion in nests, irregular nesting patterns, and melanocytes with hyperchromatic nuclei
