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This unexpected link between mitochondrial glutathione and m -AAA protease AFG3L2 might lead to new pathophysiological mechanisms under a diverse clinical spectrum of AFG3L2 mutation-associated neurodegenerative disorders that range from ataxia to parkinsonism 29,43

It is also a heavy hitter for the liver

Furthermore, upregulation of IGF-1 in primary hippocampal neuron cultures using recombinant adenovirus vector IGF-1 (Rad-IGF-1) before exposure to A oligomers (AO) reduces AO attachment to neurons

They are also being explored for off-label uses such as CKD, MASLD, substance use disorders, chronic pain, neurodegenerative disorders, and PCOS