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This aqueous solution is blended with a small amount of phenoxyethanol derived from coconut oil (use for preservative properties)

Mei, Z., Chen, J., Luo, S., Jin, L., Liu, Q., & Chen, Y

[18] Upon binding to MT1 receptors, melatonin initiates a cascade of intracellular signaling events that ultimately result in decreased neuronal firing and reduced alertness

In the context of ADRD risk, cerebral hypoperfusion also appears to precede Amyloid- (A) and hyperphosphorylated tau accumulation in the ADRD pathophysiological cascade (Iturria-Medina et al., 2016), particularly in regions vulnerable to early pathology (entorhinal cortex, hippocampus, inferior parietal cortex, inferior temporal cortex) (Mattsson et al., 2014)