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Skin improvements are typically noticeable within 4-8 weeks, with full effects developing over 3-6 months of consistent use

Biomedicine & Pharmacotherapy , 57(34), 145155

Ideal candidates include patients with acute sports injuries seeking accelerated recovery, chronic tendinopathies that have not responded to conservative management, post-surgical orthopedic cases where optimized healing is a priority, inflammatory joint conditions where traditional treatments have fallen short, and autoimmune-mediated pain where immune modulation may provide benefit

NGF binding to TrkA promotes APP to undergo non-amyloidogenic cleavage, reducing A production [85, 86]