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Individuals with a history of medullary thyroid cancer or Multiple Endocrine Neoplasia Type 2 should avoid semaglutide entirely, as GLP-1 agonists carry a theoretical increased risk of thyroid cell proliferation

Indeed, the stimulatory effect of GLP-1(2836) on glycolysis and its inhibitory effect on FAO were consistent in all vascular cell types studied and under all experimental conditions

The big problem is safety and durability That's so true, and was exactly my interpretation when first published on line