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Additional information Peer review information Nature Chemical Biology thanks Yan Zhang and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

These changes reflect both structural and homeostatic disruptions, requiring a regenerative, multifaceted approach to aesthetic treatment

Participants treated with liraglutide (239), semaglutide (240), or tirzepatide (200) in the clinical trials had a percent reduction in fat mass approximately three times greater than the reduction in lean mass, leading to an overall improvement in body composition