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The peptide undergoes rapid first-pass metabolism when absorbed, which is why bioavailability varies significantly by administration route

Pineal Melatonin Rhythm in Elderly Humans Korkushko et al., Bulletin of Experimental Biology and Medicine (2004) Korkushko and colleagues at the Institute of Gerontology in Kiev evaluated the effect of the related pineal peptide preparation epithalamin (the longer parent compound from which Epithalon was derived) on circadian melatonin secretion in elderly human subjects

This means patients get the benefit of concentrated local therapy whether PRP growth factors, Regenokine, or cells without having to tolerate the downsides of systemic drugs

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