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Aleniglipron Shows Promising Weight Loss Results in Phase 2 Trial Oral GLP-1 Drug Shows Promising Weight Loss Results in Phase 2 Trial Patients on the highest aleniglipron dose achieved up to 12% weight loss at 36 weeks A new strategy for delivering GLP-1 drugs to patients with obesity or who were overweight resulted in up to a 12 percent reduction in body weight after 36 weeks, according to a randomized phase II clinical trial published in Nature Medicine