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Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3

Subsequently, they received intravenous injections of PBS, Ru(II)-OH, NP2, or NP4 (at a dosage of 2 mg/kg Ru) on days 0, 3, 6, and 9, respectively

Histopathological examination of endomyocardial biopsies from SUN-treated patients who developed heart failure revealed cardiomyocyte hypertrophy and mitochondrial abnormalities including swelling, membrane whorls, and effaced cristae [4, 6]