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The growth-promoting effects of growth hormone include muscle tissue hypertrophy (which may be desired by some but represents an anabolic effect), bone growth and remodeling (problematic after growth plates close), organ enlargement with chronic supraphysiologic doses (cardiac hypertrophy, acromegaly features), connective tissue proliferation (potentially contributing to joint pain and carpal tunnel syndrome), and cellular proliferation that may support tumor growth in susceptible individuals

Dig Dis Sci 57:19871989

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For DHAR activity determinations, each assay consisted of 0.2 mM DHA and 1 mM GSH in 50 mM KH 2 PO 4 : K 2 HPO 4 (pH 7.0) and was initiated by the addition of 50 L of the desalted floret extract in the same buffer