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The TGA cited several key factors: Lack of Robust Clinical Evidence: While preclinical and animal studies show promise, there is a distinct lack of large-scale, high-quality human clinical trials to establish safety and efficacy for various claimed uses

Personalized treatment and metabolic response modulation: from organoids to real-time treatment adjustment With the advancement of personalized medicine, CRC treatment strategies are gradually shifting from traditional molecular subtyping toward metabolic subtyping

Prescribing information for currently approved GLP-1 receptor agonists lists established adverse effects with clear frequency data