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Interestingly, no difference in food intake was observed between wild-type mice treated with the dual incretin GLP-1/GIP coagonist and those treated with the tri-agonist despite the difference in weight loss, and this was found to be due to significantly higher ATP expenditure in tri-agonist-treated diet-induced obese mice

For mild, non-bloody diarrhoea without fever, short-course loperamide may be considered following pharmacist or clinician advice, in line with NHS self-care guidance

Research interest from institutions across the Ireland has grown rapidly alongside the broader global expansion of metabolic peptide research

J., Orskov, C., Nielsen, O