These findings validate the therapeutic targeting of the system Xc pathway, although challenges related to tumor selectivity and potential systemic toxicity remain
Loren Pickart estimated the lethal dose at approximately 22,500 mg for humans, which is 300-fold above effective doses
15 ROS include radical compounds, such as superoxide, hydroxyl radicals, and lipid hydroperoxides, and reactive nonradical compounds, such as singlet oxygen, hydrogen peroxide (H 2 O 2 ), hypochlorous acid, chloramines, and ozone
[17] [18] Women of childbearing potential should inform their healthcare provider if they are taking ALA or planning to start it, and pregnant patients should only use alpha-lipoic acid if it is prescribed by a physician who has judged that the expected benefits outweigh the possible risks