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Moreover, experimental data show that the 5-methylTHFFR- complex is secreted by the choroid plexus as an exosome with several other proteins for uptake from the CSF by the brain parenchyma (80)

A deficiency may lead to a wide range of symptoms, including: Ongoing fatigue or low energy Brain fog or difficulty concentrating Low mood or irritability Pale skin or a yellow tinge Tingling or numbness in the hands and feet Shortness of breath Dizziness or feeling faint Mouth ulcers or sore tongue Blurred vision Some of these symptoms may also be caused by iron deficiency

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