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Provides protective effects against age-related cognitive decline and neurodegeneration by supporting neuronal health, promoting synaptic resilience, and enhancing cellular repair mechanisms

Due to this relationship, scientists have theorized that IGF-1 can be used to treat diabetes, especially if started prior to puberty

We determined the crystal structures of Pa DHDPR alone, with its competitive inhibitor (dipicolinate), and the ternary complex of the enzyme with dipicolinate and NADPH, with results showing that only the ternary complex had a fully closed conformation and suggesting that binding of both substrate and nucleotide cofactor is required for enzymatic activity