PUFAs interact with coenzyme A to generate acyl-CoA via the catalytic activity of acyl-CoA synthetase long-chain family member 4 (ACSL4)
The synthesis of TMAO and crotonobetaine is strongly reduced by the administration of antibiotics, thus demonstrating that the intestinal microbiota plays an essential role in their synthesis
Such protein-based biologics can be genetically fused to either the N-terminal or C-terminal end of albumin, or to both 6,7,8,9,10,11,12,13,14,15
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