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According to our structure, the octanoyl group is located at cavity II but not cavity I, which is different from the previous modeling studies 17,18,19

writingoriginal draft preparation, J.V., L.V., L.K

doi: 10.34172/jhp.2022.23 45

Evidence note: The most cited epithalon human data including a multi-year elderly cohort originates largely from one research group, with limited independent replication beyond recent fibroblast work