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Graham MR, Ryan P, Baker JS, Davies B, Thomas NE, Cooper SM, Evans P, Easmon S, Walker CJ, Cowan D, Kicman AT

The unfolded protein response, the stress-induced quality control system of the endoplasmic reticulum, is activated not only by the accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum, but also by signaling lipids, including sphingolipids, and by the potentially harmful excess of lipid species such as saturated fatty acids, ceramides and cholesterol (Puth et al., 2015)

Suhl, E., Anderson-Haynes, S

2 ounces (57g) Suggested Adult Use: Rub 2.2 grams (1/4 tsp) of cream into the skin as needed