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The HGF/c-Met system is critical for neurogenesis, neuronal survival, neurite outgrowth, synaptic plasticity, and cerebroprotection, functions that significantly overlap with those attributed to AngIV

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The v3 integrin-binding RGD4C peptide was conjugated to PD0325901, an MEK1/2 inhibitor, via a GGGGG peptide linker, which enhanced the antitumor activity of the drug against glioblastoma 79