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Audio transcript MICHEL MARTIN, HOST: Food companies are responding to the popularity of medicines to treat obesity

A study found that the classic TCM formula, Si Miao Formula, can significantly alter the composition of the gut microbiota, specifically increasing the proportion of Akkermansia muciniphila , which can regulate the expression of genes involved in fat synthesis (e.g., decrease liver sterol regulatory element binding protein expression) and different inflammatory markers (e.g., decrease the expression of interleukin-1 (IL-1) and IL-6 and the activity of alanine transaminase and myeloperoxidase) ( Firmicutes and Bacteroidetes while reducing the number of Proteobacteria , thereby alleviating gut microbiota dysbiosis

An excessively high dose of melanotan 2, a related molecule, has been linked to priapism

And insulin resistance can make it even harder to lose weight