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APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

Certains patientes dcrivent une lgre sensation de chaleur ou de fracheur lors de la diffusion, totalement transitoire

Cureus , 14 (11), e31324

Meningococci interaction through type IV pili has been shown to induce an increase in Ca 2+ levels sufficient to redistribute LAMP1 to the plasma membrane, making it accessible to the IgA protease (Massa et al., 2017) and with Platelet Activating Factor Receptor (PAFr) (Jen et al., 2013), as demonstrated in endothelial cells and upper airway epithelial cells, respectively