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Indeed, experiments using uniformly labeled 13 C-glutamine showed that glutathione was enriched with five 13 C atoms in glutathione, suggesting that glutamine is the major source of glutathione 16,57,60

In keeping with this finding, an ACL transection (ACLT) rat model showed reduced OARSI score after subcutaneous administration of liraglutide 50 g/kg/day for 3 or 6 weeks [35]

These treatments should thus be prioritized for patients with T2D at risk for the development of NAFLD/NASH (e.g., obesity)

GLP-1 medications are best suited for individuals with a BMI of 30 or higher, or 27 and above with weight-related comorbidities like type 2 diabetes or high blood pressure