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Safety Contraindications: History of opioid use disorder risk of precipitating withdrawal Includes patients actively suboxone (buprenorphine) or methadone Pregnancy Currently pregnancy category C, ACOG does not have definitive recommendations on its use, likely needs further research specifically in this population Liver disease Previously had a black box warning for use in liver disease [13] Black box was removed in 2013 due to a lack of evidence of harm in this patient population

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Surprisingly, it is commonly seen in individuals who do not play golf

GLP-1s preferentially reduce visceral adipose tissue, making them one of the most powerful tools for metabolic restoration