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This shift reflects a major change in legal and regulatory risk, driven by federal enforcement priorities, recent proposed legislation, and aggressive intellectual property enforcement by pharmaceutical companies that hold FDA approvals for GLP-1 drugs

(2012) demonstrated that intestinal I/R injury in mice resulted in hippocampal microglial activation and upregulation of pro-inflammatory cytokines

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Accordingly, production of the endogenous antioxidant glutathione (GSH) by glial cells within the brain [8], particularly astrocytes [8,9,10], is a critical function, as most antioxidants are unable to cross the blood brain barrier