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10.1016/j.jpeds.2009.11.020

Second, some baseline characteristics, such as included population, duration of study, background therapies and quality of studies are different across included RCTs which are particularly relevant as cardiometabolic effects of GLP-1RAs may differ when these agents are added to insulin, metformin, sulfonylureas, DDP-4 inhibitors and SGLT-2 inhibitors

Through the PKA and Epac2 pathways, the activation of the GLP-1 receptor raises intracellular cyclic AMP (cAMP), which intensifies the insulin secretory response

Reminder: to properly reconstitute your peptide, bacteriostatic water is required