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One hypothesis that may explain the safety findings in this analysis is that metformin tends to be discontinued in more frail individuals, such as the elderly and those with decreased kidney function [22]

Orforglipron does not directly displace these agents but rather complements them by offering an oral alternative for patients who prefer pills or do not require maximal weight loss

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The introduction of semaglutide into the pharmacological arsenal has provided patients and healthcare providers with a powerful tool to combat the escalating global epidemic of diabetes and obesity