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Tirzepatide was associated with higher GI AEs compared to insulin (nausea OR: 13.51, vomiting OR: 8.06, diarrhea OR: 4.77, constipation OR: 7.64) and placebo (nausea OR: 3.34, vomiting OR: 3.86, diarrhea OR: 2.30, constipation OR: 2.96)

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Further studies may be obtained depending on suspected organ involvement