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Rummel NG, Chaiswing L, Bondada S, St Clair DK, Butterfield DA (2021) Chemotherapy-induced cognitive impairment: focus on the intersection of oxidative stress and TNF

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p38 and JNK are associated with pro-inflammatory response and their activation leads to the transcription of proinflammatory cytokine genes like IL-1 , TNF- , and IL-6 , matrix metalloproteinase-9 ( MMP-9 ), and adhesion molecules, VCAM-1 and ICAM-1 , which promote endothelial dysfunction, atherosclerosis and thrombosis [122128]