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This tissue distribution is pharmacologically relevant because GLP-1 receptors are expressed not only in the pancreatic islets (where they mediate insulinotropic effects) but also in the gastrointestinal tract (where they slow gastric emptying), the hypothalamus and brainstem (where they mediate appetite suppression), the cardiovascular system (where they may confer cardioprotective effects), and the kidneys (where they promote natriuresis)

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Consumption of meat, fish, dairy products, and eggs and risk of ischemic heart disease: a prospective study of 7198 incident cases among 409 885 participants in the Pan-European EPIC Cohort