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Encouraged by these results, Novo Nordisk launched the much larger SOUL trial the following year

Ligand binding to GLP-1R induces recruitment of the arrestin-TEV fusion protein to the receptor, leading to cleavage at the TEV site and the release of tTA to activate the reporter (Figure 2a)

As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA), tirzepatide produces synergistic effects like increased insulin production and release, which gives it an edge over strict GLP-1 receptor agonist such as semaglutide (Ozempic)

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